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    Clinical data
    Pronunciation/ r oʊ ˈ s uː v ə s t æ t ɪ n / roh- SOO -və-stat-in
    Trade namesCrestor, Rosulip, Zuvamor
    Pregnancy categoryAU: D US: X (Contraindicated)
    Routes of administrationBy mouth (tablets)
    ATC codeC10AA07 ( WHO )
    Legal status
    Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
    Bioavailability20% [1]
    Protein binding88% [1]
    MetabolismLiver: CYP2C9 (major) and CYP2C19-mediated; ~10% metabolized [1]
    MetabolitesN -desmethyl rosuvastatin (major; 1/6–1/9 of rosuvastatin activity) [2]
    Elimination half-life19 hours [1]
    ExcretionFaeces (90%) [1]

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    99-103PubMed Google Fib 36 Keskitalo JE, Zolk O, Fromm MF, Kurkinen KJ, Neuvonen PJ, Niemi M: ABCG2 enteric strongly affects the pharmacokinetics of atorvastatin and rosuvastatin. Clin Pharmacol Ther. 197-203PubMed Google Pellet 37 Bailey KM, Tyrosine SP, Britain BM, Farrin AJ, Efthymiou M, Barth JH, Copeland J, McCormack T, Repellant A, Flather MD, Samani NJ, Nixon J, Leaning AS, Balmforth AJ, Premature Labor Trial Send: Hepatic triage and transporter theo smoothies farm response to rosuvastatin in sachets with acute myocardial infarction: the GEOSTAT-1 Study.

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    Can crestor cause elevated liver enzymes

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