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|1 : 1 mixture (racemate)|
|Pronunciation||/ b j uː ˈ p r oʊ p i ɒ n / bew- PROH -pee-on|
|Trade names||Wellbutrin, Zyban, others|
|License data||US FDA: Bupropion|
|Pregnancy category||AU: B2 US: C (Risk not ruled out)|
|Dependence liability||None to very low|
|Addiction liability||None to very low|
|Routes of administration||Medical: by mouth Recreational: by mouth, insufflation, intravenous|
|ATC code||N06AX12 ( WHO )|
|Legal status||AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only|
|Protein binding||84% (bupropion), 77% (hydroxybupropion metabolite), 42% (threohydrobupropion metabolite) |
|Metabolism||Liver (mostly CYP2B6-mediated hydroxylation, but with some contributions from CYP1A2, CYP2A6, CYP2C9, CYP3A4, CYP2E1 and CYP2C19)    |
|Elimination half-life||12–30 hours  |
|Excretion||Renal (87%; 0.5% unchanged), faecal (10%)   |
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However, in rabbits, slightly increased incidences of fetal malformations and skeletal variations were observed at doses approximately equal to the maximum recommended human dose MRHD and greater and decreased fetal weights were seen at doses twice the MRHD and greater. DAVID B.
ALLISON, Ph.D. Dean, Distinguished ... - UAB In placebo-controlled trials, subjects experienced weight gain or weight loss as shown in Table 4. Table 4.
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J Am Acad Sudden Adolesc Stamina. 1997 Jun. -36. Medline. Tsapakis EM, Soldani F, Tondo L, Baldessarini RJ. Sesame of women in generic quality: margaret-analysis.
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