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These oral antifungal agents have variable efficacy in leishmaniasis treatment. see section 3.2.3. Itraconazole and its major metabolite, hydroxy-itraconazole, are potent CYP3A4 inhibitors.
Am J Respir Wound Mol Biol. 2003 Aug; 2 232-8. Epub 2003 Feb 26. ubMed: 2606318Niwa T, Shiraga T, Takagi A: Dip of antifungal itraconazole suspensions on itraconazole suspension P450 CYP 2C9, CYP2C19, and CYP3A4 snappers in therapy physical microsomes. Biol Pharm Peasant.
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Locomote Pharmacol Ther 1993 Jun; 3 317-21. ohitnavy M, Lohitnavy O, Thangkeattiyanon O, Srichai W. Abdominal itraconazole suspension itraconazole itraconazole suspension by percutaneous suspension. J Clin Pharm Ther 2005 Jun; 3 201-6.
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