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    Clinical data
    Pronunciation/ m ɛ t ˈ f ɔːr m ɪ n /, met- FAWR -min
    Trade namesGlucophage, other
    AHFS/Drugs.comMonograph
    MedlinePlusa696005
    License dataEU  EMA:  by INN, US   FDA: metformin
    Pregnancy categoryAU: C US: B (No risk in non-human studies)
    Routes of administrationby mouth
    ATC codeA10BA02 ( WHO )
    Legal status
    Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
    Bioavailability50–60% [2] [3]
    Protein bindingMinimal [2]
    MetabolismNot by liver [2]
    Elimination half-life4–8.7 hours [2]
    ExcretionUrine (90%) [2]

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    Nluhizarci K, Kelestimur F, Bayram F, et al. The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome. March 2018 - Prediabetes - What's Your Code Status ... With clomiphene, recombinant follicle-stimulating hormone However, improvement in the rate of live births with metformin therapy generally has not been comparable to that associated with clomiphene therapy in such women.

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