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    Pronunciation/ ˌ s p aɪ r ə n oʊ ˈ l æ k t oʊ n / SPY -rə-noh- LAK -tohn, [3] / ˌ s p ɪər -/ SPEER - [4]
    Trade namesAldactone, Spiractin, Verospiron, many others; combinations: Aldactazide (+HCTZ), Aldactide (+HFMZ), Aldactazine (+altizide), others
    AHFS/Drugs.comMonograph
    MedlinePlusa682627
    Pregnancy categoryAU: B3 US: C (Risk not ruled out)
    Routes of administrationBy mouth, [1] topical [2]
    Drug classAntimineralocorticoid; Steroidal antiandrogen
    ATC codeC03DA01 ( WHO )
    Legal status
    Legal statusUK: POM (Prescription only) US: ℞-only
    Bioavailability60–90% [5] [6] [12]
    Protein bindingSpironolactone: 88% (to albumin and AGP) [13] Canrenone: 99.2% (to albumin) [13]
    MetabolismLiver, others: • Deacetylation via CES • S -Oxygenation via FOM • S -Methylation via TMT • Dethioacetylation • Hydroxylation via CYP3A4 • Lactone hydrolysis via PON3) [5] [6] [7] [8] [9] [10] [11]
    Metabolites7α-TS, 7α-TMS, 6β-OH-7α-TMS, canrenone, others [5] [6] [14] (All three active) [15]
    Elimination half-lifeSpironolactone: 1.4 hours [5] 7α-TMS: 13.8 hours [5] 6β-OH-7α-TMS: 15.0 hrs [5] Canrenone: 16.5 hours [5]
    ExcretionUrine, bile [6]

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