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|1 : 1 mixture (racemate)|
|Pronunciation||/ b j uː ˈ p r oʊ p i ɒ n / bew- PROH -pee-on|
|Trade names||Wellbutrin, Zyban, others|
|License data||US FDA: Bupropion|
|Pregnancy category||AU: B2 US: C (Risk not ruled out)|
|Dependence liability||None to very low|
|Addiction liability||None to very low|
|Routes of administration||Medical: by mouth Recreational: by mouth, insufflation, intravenous|
|ATC code||N06AX12 ( WHO )|
|Legal status||AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only|
|Protein binding||84% (bupropion), 77% (hydroxybupropion metabolite), 42% (threohydrobupropion metabolite) |
|Metabolism||Liver (mostly CYP2B6-mediated hydroxylation, but with some contributions from CYP1A2, CYP2A6, CYP2C9, CYP3A4, CYP2E1 and CYP2C19)    |
|Elimination half-life||12–30 hours  |
|Excretion||Renal (87%; 0.5% unchanged), faecal (10%)   |
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Lohoff FW. Start of the lamina of major depressive illness. Fever Psychiatry Rep. 2010 Dec. -46.
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