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    Bupropion
    1 : 1 mixture (racemate)
    Clinical data
    Pronunciation/ b j uː ˈ p r oʊ p i ɒ n / bew- PROH -pee-on
    Trade namesWellbutrin, Zyban, others
    AHFS/Drugs.comMonograph
    MedlinePlusa695033
    License dataUS   FDA: Bupropion
    Pregnancy categoryAU: B2 US: C (Risk not ruled out)
    Dependence liabilityNone to very low
    Addiction liabilityNone to very low
    Routes of administrationMedical: by mouth Recreational: by mouth, insufflation, intravenous
    ATC codeN06AX12 ( WHO )
    Legal status
    Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
    Protein binding84% (bupropion), 77% (hydroxybupropion metabolite), 42% (threohydrobupropion metabolite) [2]
    MetabolismLiver (mostly CYP2B6-mediated hydroxylation, but with some contributions from CYP1A2, CYP2A6, CYP2C9, CYP3A4, CYP2E1 and CYP2C19) [2] [3] [4] [5]
    Elimination half-life12–30 hours [4] [6]
    ExcretionRenal (87%; 0.5% unchanged), faecal (10%) [2] [3] [4]

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